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Article

CD40 signaling synergizes with TLR-2 in the BCR independent activation of resting B cells.

PloS one - 1 Jan 2011

Jain Shweta, Chodisetti Sathi Babu, Agrewala Javed N

Abstract excerpt

Conventionally, signaling through BCR initiates sequence of events necessary for activation and differentiation of B cells. We report an alternative approach, independent of BCR, for stimulating resting B (RB) cells, by involving TLR-2 and CD40--molecules crucial for innate and adaptive immunity. CD40 triggering of TLR-2 stimulated RB cells significantly augments their activation, proliferation and...

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Share to Receptors, Antigen, B-Cell

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Source

Open in PubMed Open full text

Identifiers

PMID: 21674065
DOI: 10.1371/journal.pone.0020651
PMCID: PMC3107243

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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