Article

Chronic BCR signaling generates and maintains age-associated B cells from anergic B cells

2023-07-29

Abstract excerpt

Accumulation of age-associated B cells (ABCs) with autoreactive properties contributes to the pathogenesis of autoimmune diseases 1–5 . However, the mechanisms whereby ABCs are generated and maintained are not understood 1, 2, 4 . Here, we show that continuous stimulation of the B-cell receptor (BCR) with self-antigens plays a crucial role in ABC generation from anergic B cells and that this signal is vital for...

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Identifiers and source

Literature Corpus work: 5e5939f6-a76c-56a2-af57-7510c757287b
DOI: 10.1101/2023.07.26.550463

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