Central role of CD40 and its ligand in B lymphocyte responses to T-dependent antigens.

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Article

Central role of CD40 and its ligand in B lymphocyte responses to T-dependent antigens.

Cellular and molecular biology (Noisy-le-Grand, France) - 1 Jan 1994

Gordon J, Katira A, Holder M, MacDonald I, Pound J

Abstract excerpt

In order to mount an effective antibody response to soluble and certain other types of antigens, B cells need help from T cells. Recently, an important receptor-ligand pair has been identified as essential for successful cognate interaction between these two classes of lymphocytes. CD40 was first identified as a receptor-like molecule on B cells which when ligated by antibody could deliver signals to prime for...

Topics

Animals
Antigens, CD
Antigens, Differentiation, B-Lymphocyte
Apoptosis
B-Lymphocytes
CD40 Antigens
CD40 Ligand
Dendritic Cells
Humans
Ligands
Lymphocyte Activation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Glycoproteins

Mice

Mice, Knockout

Models, Biological

Molecular Structure

Mutation

T-Lymphocytes, Helper-Inducer

Source

Open in PubMed

Identifiers

PMID: 7524882

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7524882-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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