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Article

IFN-alpha amplifies human naive B cell TLR-9-mediated activation and Ig production.

Journal of leukocyte biology - 1 Aug 2009

Giordani L, Sanchez M, Libri I, Quaranta M G, Mattioli B, Viora M

Abstract excerpt

TLRs are a family of molecules that function as sensors for the detection of pathogens. TLR-9, expressed on B cells and pDCs, recognizes CpG motifs of unmethylated bacterial DNA and plays a role in the development of autoimmunity. The present study was designed to investigate the effects of IFN-alpha in combination with CpG ODN on the activation of CD27(-) naïve B cells and on Ig production. We provide evidence...

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PMID: 19401392
DOI: 10.1189/jlb.0908560

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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