Article
Naïve and memory B cells exhibit distinct biochemical responses following BCR engagement.
Immunology and cell biology - 1 Sept 2016
Moens Leen, Kane Alisa, Tangye Stuart G
Abstract excerpt
Immunological memory is characterized by the rapid reactivation of memory B cells that produce large quantities of high-affinity antigen-specific antibodies. This contrasts the response of naïve B cells, and the primary immune response, which is much slower and of lower affinity. Memory responses are critical for protection against infectious diseases and form the basis of most currently available vaccines....
Topics
- B-Lymphocyte Subsets
- B-Lymphocytes
- Calcium
- Cell Cycle
- Humans
- Immunoglobulin M
- Immunologic Memory
- Kinetics
- Lymphocyte Activation
- NF-KappaB Inhibitor alpha
- Phenotype
- Phosphorylation