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Article

B cells support the repair of injured tissues by adopting MyD88-dependent regulatory functions and phenotype.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Dec 2021

Sîrbulescu Ruxandra F, Mamidi Akshay, Chan Shu-Yi Claire, Jin Gina, Boukhali Myriam, Sobell Don, Ilieş Iulian, Chung Joon Yong, Haas Wilhelm, Whalen Michael J, Sluder Ann E, Poznansky Mark C

Abstract excerpt

Exogenously applied mature naïve B220+ /CD19+ /IgM+ /IgD+ B cells are strongly protective in the context of tissue injury. However, the mechanisms by which B cells detect tissue injury and aid repair remain elusive. Here, we show in distinct models of skin and brain injury that MyD88-dependent toll-like receptor (TLR) signaling through TLR2/6 and TLR4 is essential for the protective benefit of B cells in vivo,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34792819
DOI: 10.1096/fj.202101095RR
PMCID: PMC8756564

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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