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Anthrax toxin receptor 1/tumor endothelial marker 8: mutation of conserved inserted domain residues overrides cytosolic control of protective antigen binding.

Biochemistry - 31 Aug 2010

Ramey Jordan D, Villareal Valerie A, Ng Charles, Ward Sabrina C, Xiong Jian-Ping, Clubb Robert T, Bradley Kenneth A

Abstract excerpt

Anthrax toxin receptor 1 (ANTXR1)/tumor endothelial marker 8 (TEM8) is one of two known proteinaceous cell surface anthrax toxin receptors. A metal ion dependent adhesion site (MIDAS) present in the integrin-like inserted (I) domain of ANTXR1 mediates the binding of the anthrax toxin subunit, protective antigen (PA). Here we provide evidence that single point mutations in the I domain can override regulation of...

Topics

Animals
Antigens
Antigens, Bacterial
Bacterial Toxins
Biomarkers, Tumor
Cricetinae
Cytosol
Membrane Proteins
Mutation
Nitric Oxide Synthase Type III

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Structure, Secondary

Proteins

Receptors, Peptide

Source

Open in PubMed Open full text

Identifiers

PMID: 20690680
DOI: 10.1021/bi100887w
PMCID: PMC2942075

Genes

ANTXR1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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