Article

De novo designed inhibitor confers protection against lethal toxic shock

2024-08-24

Abstract excerpt

Paeniclostridium sordellii causes a toxic shock syndrome with a mortality rate of nearly 70%, primarily affecting postpartum and post-abortive women. This disease is driven by the production of the P. sordellii lethal toxin, TcsL, for which there are currently no effective treatments. We used a protein diffusion model, RFdiffusion, to design high affinity TcsL inhibitors. From a very small set of 48 starting desi...

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Literature Corpus work: 81a1ecae-8734-58d9-b999-cfab2d96d9ed
DOI: 10.1101/2024.08.23.608890

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