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Article

Osteopontin is required for full expression of the transformed phenotype by the ras oncogene.

British journal of cancer - 1 Jul 2000

Wu Y, Denhardt D T, Rittling S R

Abstract excerpt

The secreted phosphoprotein osteopontin (OPN) is strongly associated with the process of neoplastic transformation, based both on its pattern of expression in vivo and in vitro and on functional analyses. We have used 3T3 cells derived from wildtype and OPN-deficient mice and transformed by transfection with oncogenic ras to assess the role of OPN in transformation in vitro and in tumorigenesis in vivo. There was...

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Identifiers

PMID: 10901364
DOI: 10.1054/bjoc.2000.1200
PMCID: PMC2363489

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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