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Article

Chromatin remodeling underlies the senescence-associated secretory phenotype of tumor stromal fibroblasts that supports cancer progression.

Cancer research - 1 May 2012

Pazolli Ermira, Alspach Elise, Milczarek Agnieszka, Prior Julie, Piwnica-Worms David, Stewart Sheila A

Abstract excerpt

Age is a major risk factor for the development of cancer. Senescent fibroblasts, which accumulate with age, secrete protumorigenic factors collectively referred to as the senescence-associated secretory phenotype (SASP). Here, we examined the molecular mechanisms that control SASP activation, focusing on the known SASP factor osteopontin (OPN). We found that expression of the canonical SASP members interleukin...

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Identifiers

PMID: 22422937
DOI: 10.1158/0008-5472.CAN-11-3386
PMCID: PMC3605047

Genes

ATM
HDAC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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