Signalling by senescent melanocytes hyperactivates hair growth

Abstract excerpt

Abstract Niche signals maintain stem cells in a prolonged quiescence or transiently activate them for proper regeneration1. Altering balanced niche signalling can lead to regenerative disorders. Melanocytic skin nevi in human often display excessive hair growth, suggesting hair stem cell hyperactivity. Here, using genetic mouse models of nevi2,3, we show that dermal clusters of senescent melanocytes drive...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Hair Growth and Disorders
• Share to melanin and skin pigmentation
• Share to Mesenchymal stem cell research