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Article

Cancer and aging: a model for the cancer promoting effects of the aging stroma.

The international journal of biochemistry & cell biology - 1 Nov 2002

Krtolica Ana, Campisi Judith

Abstract excerpt

The incidence of cancer rises exponentially with age in humans and many other mammalian species. Malignant tumors are caused by an accumulation of oncogenic mutations. In addition, malignant tumorigenesis requires a permissive tissue environment in which mutant cells can survive, proliferate, and express their neoplastic phenotype. We propose that the age-related increase in cancer results from a synergy between...

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Identifiers

PMID: 12200035
DOI: 10.1016/s1357-2725(02)00053-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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