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Article

IER2-induced senescence drives melanoma invasion through osteopontin

5 Oct 2021

Abstract excerpt

Expression of the immediate-early response gene IER2 has been associated with the progression of several types of cancer, but its functional role is poorly understood. We found that increased IER2 expression in human melanoma is associated with shorter overall survival, and subsequently investigated the mechanisms through which IER2 exerts this effect. In experimental melanoma models, sustained expression of IER2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34611309
DOI: 10.1038/s41388-021-02027-6

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