Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Spinophilin loss contributes to tumorigenesis in vivo.

Cell cycle (Georgetown, Tex.) - 15 Jun 2011

Ferrer Irene, Peregrino Sandra, Cañamero Marta, Cecilia Yolanda, Blanco-Aparicio Carmen, Carnero Amancio

Abstract excerpt

The scaffold protein spinophilin (SPN, PPP1R9B) is a regulatory subunit of phosphatase-1a located at 17q21.31. This region is frequently associated with microsatellite instability and LOH and contains a relatively high density of known tumor suppressor genes (such as BRCA1), putative tumor suppressor genes and several unidentified candidate tumor suppressor genes located distal to BRCA1. Spn is located distal to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRCA1 Protein
Share to Chromosomes, Human, Pair 17

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mammary Neoplasms, Animal

Share to Microfilament Proteins

Share to Nerve Tissue Proteins

Share to Survival Rate

Share to Tumor Suppressor Protein p53

Share to Tumor Suppressor Proteins

Source

Identifiers

PMID: 21670604
DOI: 10.4161/cc.10.12.15798

Genes

BRCA1
SPN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Spinophilin loss contributes to tumorigenesis in vivo.PMID 21670604Read ↗

Spinophilin acts as a tumor suppressor by regulating Rb phosphorylationSemantic proximity Read ↗

Deletions linked to TP53 loss drive cancer through p53-independent mechanisms.Semantic proximity Read ↗

Mutation of SPINOPHILIN (PPP1R9B) found in human tumors promotes the tumorigenic and stemness properties of cells.Semantic proximity Read ↗

SnoN activates p53 directly to regulate aging and tumorigenesis.Semantic proximity Read ↗

The Atypical Cyclin-Like Protein Spy1 Overrides p53-Mediated Tumour Suppression and Promotes Susceptibility to Breast TumorigenesisSemantic proximity Read ↗

Haploinsufficiency of the ESCRT Component HD-PTP Predisposes to Cancer.Semantic proximity Read ↗

Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype.Semantic proximity Read ↗

Epigenetic silencing of beta-spectrin, a TGF-beta signaling/scaffolding protein in a human cancer stem cell disorder: Beckwith-Wiedemann syndrome.Semantic proximity Read ↗

Loss of Fbxw7 triggers mammary tumorigenesis associated with E2F/c-Myc activation and Trp53 mutation.Semantic proximity Read ↗

The cyclin-like protein Spy1/RINGO promotes mammary transformation and is elevated in human breast cancerSemantic proximity Read ↗

In vivo interference with Skp1 function leads to genetic instability and neoplastic transformation.Semantic proximity Read ↗

Establishment and analysis of a novel mouse line carrying a conditional knockin allele of a cancer-specific FBXW7 mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.