Article
Epigenetic silencing of beta-spectrin, a TGF-beta signaling/scaffolding protein in a human cancer stem cell disorder: Beckwith-Wiedemann syndrome.
The Journal of biological chemistry - 12 Nov 2010
Yao Zhi-Xing, Jogunoori Wilma, Choufani Sanaa, Rashid Asif, Blake Tiffany, Yao Wenguo, Kreishman Peter, Amin Rupen, Sidawy Anton A, Evans Stephen R T, Finegold Milton, Reddy E Premkumar, Mishra Bibhuti, Weksberg Rosanna, Kumar Rakesh, Mishra Lopa
Abstract excerpt
Hereditary cancer syndromes provide powerful insights into dysfunctional signaling pathways that lead to sporadic cancers. Beckwith-Wiedemann syndrome (BWS) is a hereditary human cancer stem cell syndrome currently linked to deregulated imprinting at chromosome 11p15 and uniparental disomy. Howev...
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