Article
Epigenetic silencing of beta-spectrin, a TGF-beta signaling/scaffolding protein in a human cancer stem cell disorder: Beckwith-Wiedemann syndrome.
The Journal of biological chemistry - 12 Nov 2010
Yao Zhi-Xing, Jogunoori Wilma, Choufani Sanaa, Rashid Asif, Blake Tiffany, Yao Wenguo, Kreishman Peter, Amin Rupen, Sidawy Anton A, Evans Stephen R T, Finegold Milton, Reddy E Premkumar, Mishra Bibhuti, Weksberg Rosanna, Kumar Rakesh, Mishra Lopa
Abstract excerpt
Hereditary cancer syndromes provide powerful insights into dysfunctional signaling pathways that lead to sporadic cancers. Beckwith-Wiedemann syndrome (BWS) is a hereditary human cancer stem cell syndrome currently linked to deregulated imprinting at chromosome 11p15 and uniparental disomy. However, causal molecular defects and genetic models have remained elusive to date in the majority of cases. The...
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