Article
Deletions linked to TP53 loss drive cancer through p53-independent mechanisms.
Nature - 24 Mar 2016
Liu Yu, Chen Chong, Xu Zhengmin, Scuoppo Claudio, Rillahan Cory D, Gao Jianjiong, Spitzer Barbara, Bosbach Benedikt, Kastenhuber Edward R, Baslan Timour, Ackermann Sarah, Cheng Lihua, Wang Qingguo, Niu Ting, Schultz Nikolaus, Levine Ross L, Mills Alea A, Lowe Scott W
Abstract excerpt
Mutations disabling the TP53 tumour suppressor gene represent the most frequent events in human cancer and typically occur through a two-hit mechanism involving a missense mutation in one allele and a 'loss of heterozygosity' deletion encompassing the other. While TP53 missense mutations can also contribute gain-of-function activities that impact tumour progression, it remains unclear whether the deletion event,...
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