Article
Establishment and analysis of a novel mouse line carrying a conditional knockin allele of a cancer-specific FBXW7 mutation.
Scientific reports - 31 Jan 2018
Ikenoue Tsuneo, Terakado Yumi, Zhu Chi, Liu Xun, Ohsugi Tomoyuki, Matsubara Daisuke, Fujii Tomoki, Kakuta Shigeru, Kubo Sachiko, Shibata Takuma, Yamaguchi Kiyoshi, Iwakura Yoichiro, Furukawa Yoichi
Abstract excerpt
F-box and WD40 domain protein 7 (FBXW7) is a component of the SKP1-CUL1-F-box protein (SCF) complex that mediates the ubiquitination of diverse oncogenic target proteins. The exploration of FBXW7 mutations in human primary cancer has revealed three mutation hotspots at conserved arginine residues (Arg465, Arg479, and Arg505) in the WD40 domain, which are critical for substrate recognition. To study the function...
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