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The cyclin-like protein Spy1/RINGO promotes mammary transformation and is elevated in human breast cancer

26 Jan 2012

Abstract excerpt

BACKGROUND: Spy1 is a novel 'cyclin-like' activator of the G1/S transition capable of enhancing cell proliferation as well as inhibiting apoptosis. Spy1 protein levels are tightly regulated during normal mammary development and forced overexpression in mammary mouse models accelerates mammary tumorigenesis. METHODS: Using human tissue samples, cell culture models and in vivo analysis we study the implications of...

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PMID: 22280365
DOI: 10.1186/1471-2407-12-45

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