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Article

Haploinsufficiency of the ESCRT Component HD-PTP Predisposes to Cancer.

Cell reports - 31 May 2016

Manteghi Sanaz, Gingras Marie-Claude, Kharitidi Dmitri, Galarneau Luc, Marques Maud, Yan Ming, Cencic Regina, Robert Francis, Paquet Marilène, Witcher Michael, Pelletier Jerry, Pause Arnim

Abstract excerpt

Endosomal sorting complexes required for transport (ESCRT) drive cell surface receptor degradation resulting in attenuation of oncogenic signaling and pointing to a tumor suppressor function. Here, we show that loss of function of an ESCRT protein (HD-PTP encoded by the PTPN23 gene, located on the tumor suppressor gene cluster 3p21.3) drives tumorigenesis in vivo. Indeed, Ptpn23(+/-) loss predisposes mice to...

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Source

Identifiers

PMID: 27210750
DOI: 10.1016/j.celrep.2016.04.076

Genes

PTPN23

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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