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Article

Spinophilin acts as a tumor suppressor by regulating Rb phosphorylation

15 Aug 2011

Abstract excerpt

The scaffold protein Spinophilin (SPN) is a regulatory subunit of phosphatase1a located at 17q21.33. This region is frequently associated with microsatellite instability and LOH containing a relatively high density of known tumor suppressor genes, including BRCA1. Several linkage studies have suggested the existence of an unknown tumor suppressor gene distal to BRCA1. Spn may be this gene, but the mechanism...

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PMID: 21772120
DOI: 10.4161/cc.10.16.16422

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