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Article

SnoN activates p53 directly to regulate aging and tumorigenesis.

Aging cell - 1 Oct 2012

Pan Deng, Zhu Qingwei, Conboy Michael J, Conboy Irina M, Luo Kunxin

Abstract excerpt

We have identified SnoN as a direct activator of p53 to accelerate aging and inhibit tumorigenesis. SnoN has been shown previously to promote proliferation and transformation by antagonizing TGFβ signaling. We show that elimination of this TGFβ antagonistic activity of SnoN in vivo results in accelerated aging and resistance to tumorigenesis. The SnoN knockin mice display a shortened lifespan, decreased...

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Source

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Identifiers

PMID: 22805162
DOI: 10.1111/j.1474-9726.2012.00857.x
PMCID: PMC3897278

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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