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Article

Mutation of SPINOPHILIN (PPP1R9B) found in human tumors promotes the tumorigenic and stemness properties of cells.

Theranostics - 1 Jan 2021

Verdugo-Sivianes Eva M, Rojas Ana M, Muñoz-Galván Sandra, Otero-Albiol Daniel, Carnero Amancio

Abstract excerpt

Rationale: SPINOPHILIN (SPN, PPP1R9B) is an important tumor suppressor involved in the progression and malignancy of different tumors depending on its association with protein phosphatase 1 (PP1) and the ability of the PP1-SPN holoenzyme to dephosphorylate retinoblastoma (pRB). Methods: We performed a mutational analysis of SPN in human tumors, focusing on the region of interaction with PP1 and pRB. We explored...

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Identifiers

PMID: 33537097
DOI: 10.7150/thno.53572
PMCID: PMC7847670

Genes

SPN
MB

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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