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Article

Notch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALL.

Blood - 11 Aug 2011

Tatarek Jessica, Cullion Kathleen, Ashworth Todd, Gerstein Rachel, Aster Jon C, Kelliher Michelle A

Abstract excerpt

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy largely caused by aberrant activation of the TAL1/SCL, LMO1/2, and NOTCH1 oncogenes. Approximately 30% of T-ALL patients relapse, and evidence is emerging that relapse may result from a failure to eliminate leukemia-initiating cells (LICs). Thymic expression of the Tal1 and Lmo2 oncogenes in mice results in rapid development of T-ALL; and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 21670468
DOI: 10.1182/blood-2010-08-300343
PMCID: PMC3156046

Genes

LMO1
NOTCH1
TAL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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Notch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALL.PMID 21670468Read ↗

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Activating Notch1 mutations in mouse models of T-ALL.Semantic proximity Read ↗

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Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes.Semantic proximity Read ↗

A DNA-binding mutant of TAL1 cooperates with LMO2 to cause T cell leukemia in mice.Semantic proximity Read ↗

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Disordered T-Cell Development and T-Cell Malignancies in SCL LMO1 Double-Transgenic Mice: Parallels with E2A-Deficient MiceSemantic proximity Read ↗

Notch1 Contributes to Mouse T-Cell Leukemia by Directly Inducing the Expression of c<i>-myc</i>Semantic proximity Read ↗

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