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Notch1 Contributes to Mouse T-Cell Leukemia by Directly Inducing the Expression of c<i>-myc</i>

18 Oct 2006

Abstract excerpt

Recent work with mouse models and human leukemic samples has shown that gain-of-function mutation(s) in Notch1 is a common genetic event in T-cell acute lymphoblastic leukemia (T-ALL). The Notch1 receptor signals through a gamma-secretase-dependent process that releases intracellular Notch1 from the membrane to the nucleus, where it forms part of a transcriptional activator complex. To identify Notch1 target...

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PMID: 16954387
DOI: 10.1128/mcb.01091-06

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Notch1 Contributes to Mouse T-Cell Leukemia by Directly Inducing the Expression of c<i>-myc</i>PMID 16954387Read ↗

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Deregulated NOTCH signaling in acute T-cell lymphoblastic leukemia/lymphoma: new insights, questions, and opportunities.Semantic proximity Read ↗

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Two distinct Notch1 mutant alleles are involved in the induction of T-cell leukemia in c-myc transgenic mice.Semantic proximity Read ↗

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