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Article

Transgenic expression of the human growth hormone minigene promotes pancreatic β-cell proliferation.

American journal of physiology. Regulatory, integrative and comparative physiology - 1 Oct 2015

Baan Mieke, Kibbe Carly R, Bushkofsky Justin R, Harris Ted W, Sherman Dawn S, Davis Dawn Belt

Abstract excerpt

Transgenic mouse models are designed to study the role of specific proteins. To increase transgene expression the human growth hormone (hGH) minigene, including introns, has been included in many transgenic constructs. Until recently, it was thought that the hGH gene was not spliced, transcribed, and translated to produce functional hGH protein. We generated a transgenic mouse with the transcription factor...

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Identifiers

PMID: 26202070
DOI: 10.1152/ajpregu.00244.2015
PMCID: PMC4631542

Genes

MIP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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