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PIK3CA-mediated PI3-kinase signalling is essential for HPV-induced transformation in vitro

10 Jun 2011

Abstract excerpt

BACKGROUND: High-risk human papillomavirus (hrHPV) infections are causally related to cervical cancer development. The additional (epi)genetic alterations driving malignant transformation of hrHPV-infected cells however, are not yet fully elucidated. In this study we experimentally assessed the role of the PI3-kinase pathway and its regulator PIK3CA, which is frequently altered in cervical cancer, in HPV-induced...

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PMID: 21663621
DOI: 10.1186/1476-4598-10-71

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