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Article

PIK3CA dependence and sensitivity to therapeutic targeting in urothelial carcinoma.

BMC cancer - 28 Jul 2016

Ross R L, McPherson H R, Kettlewell L, Shnyder S D, Hurst C D, Alder O, Knowles M A

Abstract excerpt

BACKGROUND: Many urothelial carcinomas (UC) contain activating PIK3CA mutations. In telomerase-immortalized normal urothelial cells (TERT-NHUC), ectopic expression of mutant PIK3CA induces PI3K pathway activation, cell proliferation and cell migration. However, it is not clear whether advanced UC tumors are PIK3CA-dependent and whether PI3K pathway inhibition is a good therapeutic option in such cases. METHODS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27465249
DOI: 10.1186/s12885-016-2570-0
PMCID: PMC4964013

Genes

PTEN
TSC1
AKT1
TERT

Provenance

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