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Molecular analysis of the PI3K‐AKT pathway in uterine cervical neoplasia: Frequent <i>PIK3CA</i> amplification and AKT phosphorylation

14 Nov 2005

Abstract excerpt

Uterine cervical carcinogenesis is probably dependent on cellular genetic damage in addition to the integration of high-risk HPV DNA in the epithelial cell genome. Gain of chromosome 3q24-29 is commonly observed in cervical neoplasia. The putative oncogene PIK3CA located in this region encodes a phosphatidylinositol 3-kinase (PI3K). In a process reversed by PTEN, PI3K generates inositol phospholipids that trigger...

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PMID: 16287065
DOI: 10.1002/ijc.21461

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