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Article

A signature of balancing selection in the region upstream to the human UGT2B4 gene and implications for breast cancer risk.

Human genetics - 1 Dec 2011

Sun Chang, Huo Dezheng, Southard Catherine, Nemesure Barbara, Hennis Anselm, Cristina Leske M, Wu Suh-Yuh, Witonsky David B, Olopade Olufunmilayo I, Di Rienzo Anna

Abstract excerpt

UDP-glucuronosyltransferase 2 family, polypeptide B4 (UGT2B4) is an important metabolizing enzyme involved in the clearance of many xenobiotics and endogenous substrates, especially steroid hormones and bile acids. The HapMap data show that numerous SNPs upstream of UGT2B4 are in near-perfect linkage disequilibrium with each other and occur at intermediate frequency, indicating that this region might contain a...

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PMID: 21660508
DOI: 10.1007/s00439-011-1025-6
PMCID: PMC4478588

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