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Article

Comparative and evolutionary pharmacogenetics of ABCB1: complex signatures of positive selection on coding and regulatory regions.

Pharmacogenetics and genomics - 1 Aug 2007

Wang Haijian, Ding Keyue, Zhang Yang, Jin Li, Kullo Iftikhar J, He Fuchu

Abstract excerpt

BACKGROUND: As a major mediator in the complex interplay between humans and the xenobiotic environment, the ABCBI transporter gene is an obvious candidate for comparative and evolutionary pharmacogenetic studies. It has been recently reported that common variants in its coding region, which are variously associated with drug response and disease susceptibility, may have conferred differential selective sweep in...

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Identifiers

PMID: 17622943
DOI: 10.1097/FPC.0b013e328165249f

Genes

ABCB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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