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Article

Adaptive evolution of UGT2B17 copy-number variation.

American journal of human genetics - 1 Sept 2008

Xue Yali, Sun Donglin, Daly Allan, Yang Fengtang, Zhou Xue, Zhao Mengyao, Huang Ni, Zerjal Tatiana, Lee Charles, Carter Nigel P, Hurles Matthew E, Tyler-Smith Chris

Abstract excerpt

The human UGT2B17 gene varies in copy number from zero to two per individual and also differs in mean number between populations from Africa, Europe, and East Asia. We show that such a high degree of geographical variation is unusual and investigate its evolutionary history. This required first reinterpreting the reference sequence in this region of the genome, which is misassembled from the two different alleles...

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Identifiers

PMID: 18760392
DOI: 10.1016/j.ajhg.2008.08.004
PMCID: PMC2556428

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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