Article
Comprehensive Analysis of ABCG2 Genetic Variation in the Polish Population and Its Inter-Population Comparison.
Genes - 29 Sept 2020
Słomka Marcin, Sobalska-Kwapis Marta, Korycka-Machała Małgorzata, Dziadek Jarosław, Bartosz Grzegorz, Strapagiel Dominik
Abstract excerpt
ATP-binding cassette sub-family G member 2 (ABCG2), also known as breast cancer resistance protein (BCRP), is one of the key efflux ATP-binding cassette (ABC) transporters of xenobiotics, their metabolites and endogenous compounds such as urate. Some of its genetic variants have been found to influence protein functioning, resulting in serious clinical implications concerning chemotherapy response, as well as...
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