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Article

Genetic signature consistent with selection against the CYP3A4*1B allele in non-African populations.

Pharmacogenetics and genomics - 1 Jan 2006

Schirmer Markus, Toliat Mohammad R, Haberl Michael, Suk Anita, Kamdem Landry K, Klein Kathrin, Brockmöller Jürgen, Nürnberg Peter, Zanger Ulrich M, Wojnowski L

Abstract excerpt

Cytochrome P450 3A enzymes (CYP3A) play a major role in the metabolism of steroid hormones, drugs and other chemicals, including many carcinogens. The individually variable CYP3A expression, which remains mostly unexplained, has been suggested to affect clinical phenotypes. We investigated the CY...

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Identifiers

PMID: 16344723
DOI: 10.1097/01.fpc.0000182779.03180.ba

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16344723-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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