Article

Signatures of co-evolution and co-regulation in the CYP3A and CYP4F genes in humans

2023-02-24

Abstract excerpt

1 Cytochromes P450 (CYP450) are hemoproteins generally involved in the detoxification of the body of xenobiotic molecules. They participate in the metabolism of many drugs and genetic polymorphisms in humans have been found to impact drugs responses and metabolic functions. In this study, we investigate the genetic diversity for CYP450 genes. We found that two clusters, CYP3A and CYP4F , are notably differentia...

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Literature Corpus work: f6cd36b8-35d8-541f-bad4-d4bbf84c7e94
DOI: 10.1101/2023.02.23.529697

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