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Article

Functional polymorphism of cyclooxygenase-2 gene (G-765C) in chronic obstructive pulmonary disease patients.

Molecular biology reports - 1 Mar 2012

Pietras Tadeusz, Szemraj Janusz, Panek Michał, Witusik Andrzej, Banasiak Maciej, Antczak Adam, Górski Paweł

Abstract excerpt

Cyclooxygenase two (COX-2) is an important enzyme metabolizing arachidonic acid. In contrast to constitutive cyclooxygenase one (COX-1), COX-2 is induced by proinflammatory factors. Polymorphism -765 G/C in COX-2-encoding gene promoter is associated with development of Alzheimer's disease, depression, carcinoma of the pancreas in smokers, breast cancer and rheumatoid arthritis. It is interesting whether the -765...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21655952
DOI: 10.1007/s11033-011-0964-2

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