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Polymorphisms rs2745557 in PTGS2 and rs2075797 in PTGER2 are associated with the risk of chronic obstructive pulmonary disease development in a Tunisian cohort.

Prostaglandins, leukotrienes, and essential fatty acids - 1 Mar 2021

Mani Salma, Norel Xavier, Varret Mathilde, Bchir Sarra, Ben Anes Amel, Garrouch Abdelahamid, Tabka Zouhair, Longrois Dan, Chahed Karim

Abstract excerpt

We hypothesized that polymorphisms of genes involved in the prostaglandin pathway could be associated with COPD. In this study we explored the involvement of genetic polymorphisms in PTGS2, PTGER2 and PTGER4 genes in the development and severity of COPD and their effects on plasma concentrations of inflammatory/oxidative stress markers. We identified genotypes of PTGS2, PTGER2 and PTGER4 SNPs in a Tunisian cohort...

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PMID: 33545665
DOI: 10.1016/j.plefa.2021.102252

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