Article
COX2 and p53 risk-alleles coexist in COPD.
Clinica chimica acta; international journal of clinical chemistry - 1 Nov 2008
Arif Ehtesham, Vibhuti Arpana, Deepak Desh, Singh Bhawani, Siddiqui Mohd Saeed, Pasha M A Qadar
Abstract excerpt
BACKGROUND: Cigarette smoke stimulates airway epithelial cells to release pro-inflammatory cytokines which influence various inflammation-related genes, including COX2, whereas p53 expression is known to alter in such a condition. Since both the genes share several common physiological functions including inflammation and oxidative stress, we investigated within gene and gene-gene interactions towards...
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