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Article

COX-2 rs5275 and rs689466 polymorphism and risk of lung cancer: A PRISMA-compliant meta-analysis.

Medicine - 1 Aug 2018

Li Jiaxi, Lu Xiaochen, Zou Xinwei, Jiang Yufeng, Yao Jie, Liu Hongtao, Ni Bin, Ma Haitao

Abstract excerpt

BACKGROUND: Cyclooxygenase-2 (COX-2) is an inducible enzyme that mediates the synthesis of prostaglandin, which plays an important role in the inflammation response. The overexpression of COX-2 in lung cancer has been found in several studies, suggesting that COX-2 contributes to carcinogenesis. There are many previous case-control studies focused on the association between COX-2 polymorphism and lung cancer...

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Identifiers

PMID: 30170377
DOI: 10.1097/MD.0000000000011859
PMCID: PMC6393127

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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