Article
Association of a common polymorphism in the cyclooxygenase 2 gene with risk of non-small cell lung cancer.
Carcinogenesis - 1 Feb 2004
Campa Daniele, Zienolddiny Shanbeh, Maggini Valentina, Skaug Vidar, Haugen Aage, Canzian Federico
Abstract excerpt
Studies have indicated that inflammation, in conjunction with the production of reactive oxygen species, may play a key role in lung cancer development. In this study, 250 lung cancer patients and 214 controls were genotyped for polymorphisms of the inflammation-related genes prostaglandin synthase-2/cyclooxygenase-2 (COX2/PTGS2), interleukin-6 (IL6), interleukin-8 (IL8) and peroxisome proliferator-activated...
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