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Article

Identifying overlapping mutated driver pathways by constructing gene networks in cancer.

BMC bioinformatics - 1 Jan 2015

Wu Hao, Gao Lin, Li Feng, Song Fei, Yang Xiaofei, Kasabov Nikola

Abstract excerpt

BACKGROUND: Large-scale cancer genomic projects are providing lots of data on genomic, epigenomic and gene expression aberrations in many cancer types. One key challenge is to detect functional driver pathways and to filter out nonfunctional passenger genes in cancer genomics. Vandin et al. introduced the Maximum Weight Sub-matrix Problem to find driver pathways and showed that it is an NP-hard problem. METHODS:...

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Identifiers

PMID: 25859819
DOI: 10.1186/1471-2105-16-S5-S3
PMCID: PMC4402595

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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