Article
A pharmacogenetic study of risperidone on histamine H3 receptor gene (HRH3) in Chinese Han schizophrenia patients.
Journal of psychopharmacology (Oxford, England) - 1 Jun 2012
Wei Zhiyun, Wang Lei, Zhang Mengmeng, Xuan Jiekun, Wang Yang, Liu Baocheng, Shao Liyan, Li Jun, Zeng Zhen, Li Tao, Liu Jie, Wang Ti, Zhang Ming, Qin Shengying, Xu Yifeng, Feng Guoyin, He Lin, Xing Qinghe
Abstract excerpt
Evidence suggests that the human histamine H3 receptor (HRH3) may be involved in the pharmacodynamics of risperidone and influence clinical efficacy. More information on the pharmacogenetics of this receptor may therefore be useful in developing individualized therapy. However, to our knowledge, no study has been reported in this area. The aim of this investigation was to clarify whether H3 receptor polymorphism...
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