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Article

Impact of histamine receptors H1 and H3 polymorphisms on antipsychotic-induced weight gain.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry - 1 Jan 2018

Tiwari Arun K, Zhang Danning, Pouget Jennie G, Zai Clement C, Chowdhury Nabilah I, Brandl Eva J, Qin Li, Freeman Natalie, Lieberman Jeffrey A, Meltzer Herbert Y, Kennedy James L, Müller Daniel J

Abstract excerpt

OBJECTIVES: A positive correlation between antipsychotic-induced weight gain (AIWG) and the antagonist effect of antipsychotic drugs at the histamine H1 receptor (HRH1) as well as the agonist effect at the histamine H3 receptor (HRH3) in the brain has been consistently demonstrated. We investigated the potential impact of single-nucleotide polymorphisms (SNPs) in HRH1 and HRH3 genes on AIWG. METHODS: We analysed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Source

Identifiers

PMID: 27855565
DOI: 10.1080/15622975.2016.1262061

Genes

HRH1
HRH3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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