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Effects of the dopamine D3 receptor (DRD3) gene polymorphisms on risperidone response: a pharmacogenetic study.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jan 2008

Xuan Jiekun, Zhao Xinzhi, He Guang, Yu Lan, Wang Lei, Tang Wei, Li Xingwang, Gu Niufan, Feng Guoyin, Xing Qinghe, He Lin

Abstract excerpt

Previous observations of the anatomical distribution and pharmacological profile of the dopamine D(3) receptor (DRD3) have indicated its potential role in antipsychotic drug action. Risperidone, an effective first-line atypical antipsychotic agent, exhibits a relatively high affinity for this receptor. Recent studies have reported an association of the Ser9Gly polymorphism in the DRD3 gene with therapeutic...

Topics

Adult
Age of Onset
Antipsychotic Agents
DNA
Humans
Polymerase Chain Reaction
Polymorphism, Genetic
Polymorphism, Single Nucleotide
Receptors, Dopamine D3
Risperidone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Schizophrenia

Source

Identifiers

PMID: 17429404
DOI: 10.1038/sj.npp.1301418

Genes

DRD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Effects of the dopamine D3 receptor (DRD3) gene polymorphisms on risperidone response: a pharmacogenetic study.PMID 17429404Read ↗

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