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Article

Dopamine D3 receptor Ser9Gly polymorphism and risperidone response.

Journal of clinical psychopharmacology - 1 Feb 2005

Lane Hsien-Yuan, Hsu Shih-Kuan, Liu Yi-Ching, Chang Yue-Cune, Huang Chiung-Hsien, Chang Wen-Ho

Abstract excerpt

Risperidone is an atypical antipsychotic agent with efficacy for both positive and negative symptoms of schizophrenia. Risperidone is a potent dopamine D3 antagonist and agonism at D3 sites induces behavioral suppression in rodents. We thus hypothesized that D3 antagonism may contribute to response to risperidone in negative symptoms. This study aimed to explore the influence of the Ser9Gly polymorphism of the...

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Source

Identifiers

PMID: 15643094
DOI: 10.1097/01.jcp.0000150226.84371.76

Genes

DRD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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