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Article

Genetic variation in the glutathione synthesis pathway, air pollution, and children's lung function growth.

American journal of respiratory and critical care medicine - 15 Jan 2011

Breton Carrie V, Salam Muhammad T, Vora Hita, Gauderman W James, Gilliland Frank D

Abstract excerpt

RATIONALE: Glutathione plays an important role in antioxidant and inflammatory processes in the lung. Alterations in glutathione metabolism are a central feature of several chronic lung diseases. OBJECTIVES: To determine whether sequence variation in genes in the glutathione synthesis pathway alters susceptibility to air pollution effects on lung function. METHODS: In this prospective study, 14,821 lung function...

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Source

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Identifiers

PMID: 20802163
DOI: 10.1164/rccm.201006-0849OC
PMCID: PMC3040392

Genes

GSS
FEV
GCLC
GCLM
GSR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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