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Article

Characterization of sublines of HL-60 human leukemia cells resistant to induction of differentiation by butyric acid.

Leukemia - 1 Apr 1990

Fischkoff S A, Hoessly M C, Rossi R M

Abstract excerpt

HL-60 human leukemia cells undergo terminal differentiation when cultured with butyric acid. To produce cells resistant to the maturation-inducing effects of butyric acid, two strategies were followed. First, HL-60 cells were mutagenized and cultured in soft agar with inducing concentrations of butyric acid. Four clones were isolated resistant to a wide variety of differentiation inducers, including butyric acid....

Topics

Butyrates
Butyric Acid
Cell Cycle
Cell Differentiation
Drug Resistance
Ethyl Methanesulfonate
Histone Deacetylases
Humans
Leukemia, Experimental
Leukemia, Myeloid
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Peroxidase

Tumor Cells, Cultured

Source

Identifiers

PMID: 2164121

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2164121-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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