Article
Regulation of leukotriene-biosynthetic enzymes during differentiation of myelocytic HL-60 cells to eosinophilic or neutrophilic cells.
European journal of biochemistry - 1 Aug 1996
Scoggan K A, Nicholson D W, Ford-Hutchinson A W
Abstract excerpt
Leukotrienes (LTs) are potent mediators of bronchial inflammation and are predominantly produced by myeloid cells. As myelocytic cells differentiate towards either eosinophils or neutrophils, the profile of leukotrienes they produce upon stimulation diverges. Eosinophils produce mainly cysteinyl...
Topics
- 5-Lipoxygenase-Activating Proteins
- Arachidonate 5-Lipoxygenase
- Carrier Proteins
- Cell Differentiation
- Eosinophils
- Epoxide Hydrolases
- Glutathione Transferase
- HL-60 Cells
- Humans
- Leukemia, Myeloid
- Leukotriene B4
- Leukotrienes
- Membrane Proteins
- Neutrophils
- Phenotype