Article
Reversible macrophage differentiation induced in a new human myeloid cell line by gamma interferon.
Cell biology international - 1 Jan 1995
Pintér C, Magnani I, Paini C, Clivio A
Abstract excerpt
A new cell line was established from the bone marrow of a patient with chronic myeloid leukemia. The cells were attributed an intermediate myeloid phenotype on the basis of their cytochemical features and membrane antigen expression. These cells respond to both chemical and physiological activators of the signal transduction pathways with growth arrest and phenotype changes. Macrophage maturation can be induced...
Topics
- Adult
- Bone Marrow Cells
- Cell Differentiation
- Humans
- Interferon-gamma
- Karyotyping
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Macrophages
- Male
- Phenotype
- Tumor Cells, Cultured