Among 17 inducers of differentiation only sodium butyrate causes a permanent down-regulation of c-myc in Burkitt's lymphoma.

doi:10.1002/ijc.2910620609

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Article

Among 17 inducers of differentiation only sodium butyrate causes a permanent down-regulation of c-myc in Burkitt's lymphoma.

International journal of cancer - 15 Sept 1995

Rottleb C, Bornkamm G W, Polack A

Abstract excerpt

De-regulation of c-myc by chromosomal translocation is one crucial step for the development of Burkitt's lymphoma. The de-regulation is caused through juxtaposition of c-myc with one of the 3 immunoglobulin loci. We have reported earlier that treatment of Burkitt's lymphoma cells with n-butyrate...

Topics

Alleles
Burkitt Lymphoma
Butyrates
Butyric Acid
Cell Differentiation
Down-Regulation
Gene Expression Regulation, Neoplastic
Genes, myc
Humans
Translocation, Genetic
Tumor Cells, Cultured

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