Article
Isolation and characterization of HL-60 cell variants with different potentials for spontaneous differentiation.
Leukemia - 1 Oct 1991
Fibach E, Peled T, Fibich T, Rachmilewitz E A
Abstract excerpt
Although HL-60 cells, an in vitro established cell line derived from a patient with acute promyelocytic leukemia, are blocked at the promyelocytic stage of myeloid differentiation, certain chemicals can induce the cells to undergo terminal differentiation into either granulocytes or macrophages. Moreover, a small fraction of the cell population undergoes differentiation spontaneously without the addition of any...
Topics
- Cell Differentiation
- Clone Cells
- Genetic Variation
- Humans
- Leukemia, Experimental
- Leukemia, Myeloid
- Tumor Cells, Cultured